Renal denervation in 2019

Renal Denervation

Type 2 diabetes mellitus (T2DM) is a group of metabolic diseases of multiple etiologies. Although great progress has been made, researchers are still working on the pathogenesis of T2DM and how to best use the treatments available. Aside from several novel pharmacological approaches, catheter-based sympathetic renal denervation (RDN) has gained a significant role in resistant hypertension, as w...

Ruminations About Renal Denervation.

Renal denervation for hypertension.

Systemic hypertension is a major burden to the individual and society. Its association with major adverse cardiac and cerebral events and favorable effects of antihypertensive therapy are undisputed. However, despite multidrug therapy, blood pressures are frequently suboptimally controlled. Moreover, adverse drug effects often interfere with patients' lifestyles and affect compliance. Therefore...

Renal denervation supersensitivity revisited.

To determine whether the chronically denervated kidney is supersensitive to either physiological or pathophysiological plasma levels of norepinephrine (NE), studies were conducted in conscious dogs subjected to unilateral renal denervation and surgical division of the urinary bladder into hemibladders to allow separate 24-h urine collection from denervated and innervated kidneys. Plasma NE conc...

Renal Denervation: An Update

Systemic hypertension (sHTN) remains a major health problem worldwide with an estimated 1 billion people affected by the disease and this figure is projected to reach 1.5 billion by 2025.1,2 Resistant hypertension (rHTN) is defined as failure to attain goal blood pressures (BP’s) despite treatment with optimal doses of three or more antihypertensive medications including a diuretic. Although th...